X-Ray Diffractometry & Other Analytical Techniques

Graphical abstract from “Estimation of drug particle size in intact tablets by two dimensional X-ray diffractometry.” published in J. Pharm. Sci., 107(1), 231-238, (2018).
Reprinted from Thakral, Seema, Naveen K. Thakral, and Raj Suryanarayanan. "Estimation of drug particle size in intact tablets by 2-dimensional X-ray diffractometry." Journal of pharmaceutical sciences 107.1 (2018): 231-238. Copyright (2018), with permission from Elsevier
Publication YearCitation
2023D. Yong, J. Li, W. Xu, A. Cote, A. Lay-Fortenbery, R. Suryanarayanan, and Yongchao Su. Solid-State NMR Spectroscopy to Probe State and Phase Transitions in Frozen Solutions. Mol. Pharm, 20: 6380-6390 (2023).
2023J. Sonje, S. Thakral, S. Krueger, R. Suryanarayanan. Enabling Efficient Design of Biological Formulations Through Advanced Characterization. Pharm Res, 40: 1459-1477 (2023).
2021N. Kaur, G. Haustad, R. Suryanarayanan, Use of Atomic Force Microscopy (AFM) to monitor surface crystallization in caffeine-oxalic acid (CAFOXA) cocrystal compacts. Int J Pharm, 609, 121196 (2021).
2021J. Sonje, S. Thakral, S. Krueger, R. Suryanarayanan, Reversible self-association in lactate dehydrogenase during freeze-thaw in buffered solutions using neutron scattering. Mol Pharm, 18(12), 4459-4474 (2021).
2021B. Munjal, R. Suryanarayanan, Applications of synchrotron powder X-ray diffractometry in drug substance and drug product characterization. TrAC Trends in Analytical Chemistry, 136: 116181 (2021).
2020K. K. Amponsah-Efah, B. Demeler, R. Suryanarayanan, Characterizing Drug-Polymer Interactions in Aqueous Solution with Analytical Ultracentrifugation, Mol Pharm, 18(1), 246-256 (2020).
2020A.A. Thorat, B. Munjal, T.W. Geders, R. Suryanarayanan, Freezing-induced protein aggregation – Role of pH shift and potential mitigation strategies. J Control Release, 323, 591-599 (2020).
2018S. Thakral, N.K. Thakral, R. Suryanarayanan, Estimation of drug particle size in intact tablets by two dimensional X-ray diffractometry. J Pharm Sci, 107(1), 231-238, (2018).
2017S. Koranne, R. Govindarajan, R. Suryanarayanan, Investigation of spatial heterogeneity of salt disproportionation in tablets by synchrotron X-ray diffractometry. Mol Pharm, 14(4), 1133-1144 (2017).
2017P. Mistry, K. K. Amponsah-Efah, R. Suryanarayanan, Rapid assessment of the physical stability of amorphous solid dispersions. Cryst Growth Des, 17, 2478-2485 (2017).
2016M. Mehta, R. Suryanarayanan, Accelerated physical stability testing of amorphous dispersions. Mol Pharm, 13(8), 2661-2666 (2016).
2016S. Thakral, M.W. Terban, N.K. Thakral, R. Suryanarayanan, Recent advances in the characterization of amorphous pharmaceuticals by X-ray diffractometry. Adv Drug Deliv Rev, 100: 183-193 (2016).
2015N. Thakral, S. Mohapatra, G. Stephenson, R. Suryanarayanan, Compression-induced crystallization of amorphous indomethacin in tablets: Characterization of spatial heterogeneity by two-dimensional X-ray diffractometry. Mol Pharm, 12(1), 253-263 (2015).
2015N.K. Thakral, H. Yamada, G.A. Stephenson, R. Suryanarayanan, Spatial distribution of trehalose dihydrate crystallization in tablets by X-ray diffractometry. Mol Pharm, 12(10), 3766-3775 (2015).
2014R. Govindarajan, M. Landis, B. Hancock, L. Gatlin, R. Suryanarayanan, E. Shalaev, Surface acidity and solid-state compatibility of excipients with an acid-sensitive API: Case study of atorvastatin calcium. AAPS PharmSciTech, 16(2), 354-363 (2014).
2014K. Kothari, V. Ragoonanan, R. Suryanarayanan, Dielectric spectroscopy of small molecule pharmaceuticals – effect of sample configuration. J Pharm Sci, 103(10), 3190-3196 (2014).
2014V. Ragoonanan, R. Suryanarayanan, Ultrasonication as a potential tool to predict solute crystallization in freeze-concentrates. Pharm Res, 31(6), 1512-1524 (2014).
2014R. Govindarajan, M. Landis, B. Hancock, L.A. Gatlin, R. Suryanarayanan, E.Y. Shalaev, Surface acidity and solid-state compatibility of excipients with an acid-sensitive API: case study of atorvastatin calcium. AAPS PharmSciTech, 16(2), 1-10 (2014).
2013N. Thakral, V. Ragoonanan, R. Suryanarayanan, Quantification, mechanism, and mitigation of active ingredient phase transformation in tablets. Mol Pharm, 10(8), 3128-3126 (2013).
2012P. Sundaramurthi, R. Suryanarayanan, Calorimetry and complimentary techniques to characterize frozen and freeze-dried systems. Adv Drug Del Rev, 63(13), 1118-1159 (2012)
2012S. Bhardwaj, R. Suryanarayanan, Use of dielectric spectroscopy to monitor molecular mobility in glassy and supercooled trehalose. J Phys Chem, 116(38), 11728-11736 (2012).

Previous publications can be found on Professor Sury's Google Scholar page at this link.