Pharmaceutical formulations are generally multicomponent systems, providing numerous possibilities of excipient-excipient and active-excipient interactions, thereby leading to solid form alterations, induced deliberately or inadvertently during processing. Such alterations may either result in desirable product attributes, or adverse effects in product quality. We are actively conducting research in understanding such interactions and their impact on product performance, with a view towards improving the existing knowledge space for the development of such formulations.
Papers to read
- Kaur, Navpreet, and Raj Suryanarayanan. "Investigating the Influence of Excipients on the Stability of Levothyroxine Sodium Pentahydrate." Molecular Pharmaceutics (2021).
- K. K. Amponsah-Efah, C. Glorieux, J. Thoen, R. Suryanarayanan, Effect of glycerol on the order of the mesophase transitions of super-cooled itraconazole. J Mol Liquids, 114222 (2020).
- S. Koranne, R. Lalge, R. Suryanarayanan, Modulation of Microenvironmental Acidity: A Strategy to Mitigate Salt Disproportionation in Drug Product Environment. Mol. Pharm., 17(4), 1324-1334, (2020)
- N.K. Duggirala, J. Li, N.S.K. Kumar, T. Gopinath, R. Suryanarayanan, A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability. Chem Commun. 55(39), 5551-5554 (2019)
- N.K. Duggirala, A. Vyas, J.F. Krzyzaniak, K.K. Arora, R. Suryanarayanan. Mechanistic insight into caffeine-oxalic cocrystal dissociation in formulations: Role of excipients. Mol. Pharm., 14(11), 3879-3887 (2017).
- M. Mehta, R. Suryanarayanan. Accelerated physical stability testing of amorphous dispersions. Mol. Pharm., 13(8), 2661-2666, PMID: 27299377 (2016).