Amorphous Pharmaceuticals

2023

• R. Lalge, N.S. Krishna Kumar, R. Suryanarayanan. Understanding the Effect of Nucleation in Amorphous Solid Dispersions through Time-Temperature Transformation. Mol Pharm, 20(8), 4196-4209 (2023).
• R. Lalge, N.S. Krishna Kumar, R. Suryanarayanan. Implications of Drug-Polymer Interactions on Time-Temperature-Transformation: A Tool to Assess the Crystallization Propensity in Amorphous Solid Dispersions. Mol Pharm, 20(3), 1806-1817 (2023).

2022

• J. Li, N.K. Duggirala, N.S. Krishna Kumar, Y. Su, R. Suryanarayanan. Design of ternary amorphous solid dispersions for enhanced dissolution of drug combinations. Mol Pharm, 19(8), 2950-2961 (2022).
• R. Lalge, N. Kaur, N.K. Duggirala, R. Suryanarayanan. Dual functionality of bile acid: Physical stabilization of drugs in the amorphous form and solubility enhancement in solution. Mol Pharm, 19(7), 2595-2606 (2022).
• N.S. Krishna Kumar, R. Suryanarayanan. Crystallization Propensity of Amorphous Pharmaceuticals: Kinetics and Thermodynamics. Mol Pharm, 19(2), 472-483 (2022).

2021

• K.K. Amponsah-Efah, P. Mistry, R. Eisenhart, R. Suryanarayanan. The Influence of the Strength of Drug-Polymer Interactions on the Dissolution of Amorphous Solid Dispersions. Mol Pharm, 18(1), 174-186 (2021).

2020

• A. Sahoo, R. Suryanarayanan, R.A. Siegel. Stabilization of amorphous drugs by polymers: The role of overlap concentration (C*). Mol Pharm, 17(11), 4401-4406 (2020).
• K.K. Amponsah-Efah, B. Demeler, R. Suryanarayanan. Characterizing Drug-Polymer Interactions in Aqueous Solution with Analytical Ultracentrifugation. Mol Pharm, 18(1), 246-256 (2020).

2019

• A. Sahoo, N.S. Krishna Kumar, R. Suryanarayanan. Crosslinking: An avenue to develop stable amorphous solid dispersion with high drug loading and tailored physical stability. J Control Release, 311-312, 212-224 (2019).
• N.K. Duggirala, J. Li, N.S.K. Kumar, T. Gopinath, R. Suryanarayanan. A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability. Chem Commun, 55(39), 5551-5554 (2019). *This article provided an inside back cover image for this issue upon request from the journal.

2018

• M.H. Fung, R. Suryanarayanan. Effect of organic acids on molecular mobility, physical stability and dissolution of ternary ketoconazole spray dried dispersions. Mol Pharm, 16(1), 41-48 (2018).
• M.H. Fung, M. DeVault, K.T. Kuwata, R. Suryanarayanan. Drug-excipient interactions: effect on molecular mobility and physical stability of ketoconazole-organic acid coamorphous systems. Mol Pharm, 15(3), 1052-1061 (2018).
• M.H. Fung, K. Bērziņš, R. Suryanarayanan. Physical stability and dissolution behavior of ketoconazole-organic acid coamorphous systems. Mol Pharm, 15(5), 1862-1869 (2018).
• K. Berzins, R. Suryanarayanan. Compression-induced crystallization in sucrose-polyvinylpyrrolidone amorphous solid dispersions. Cryst Growth Des, 18(2), 839-848 (2018).

2017

• P. Mistry, K.K. Amponsah-Efah, R. Suryanarayanan. Rapid assessment of the physical stability of amorphous solid dispersions. Cryst Growth Des, 17, 2478-2485 (2017).
• S. Mohapatra, S. Samanta, K. Kothari, P. Mistry, R. Suryanarayanan. Effect of polymer molecular weight on the crystallization behavior of indomethacin amorphous solid dispersions. Cryst Growth Des, 17(6), 3142-3150 (2017).
• M.H. Fung, R. Suryanarayanan. Use of a plasticizer for physical stability prediction of amorphous solid dispersions. Cryst Growth Des,17(6), 4315-4325 (2017).

2016

• M. Mehta, R. Suryanarayanan. Accelerated physical stability testing of amorphous dispersions. Mol Pharm, 13(8), 2661-2666 (2016).
• S. Thakral, M.W. Terban, N.K. Thakral, R. Suryanarayanan. Recent advances in the characterization of amorphous pharmaceuticals by X-ray diffractometry. Adv Drug Deliv Rev, 100, 183-193 (2016).
• M. Mehta, K. Kothari, V. Ragoonanan, R. Suryanarayanan. Effect of Water on Molecular Mobility and Physical Stability of Amorphous Pharmaceuticals. Mol Pharm, 13(4), 1339-1346 (2016).
• M. Mehta, V. Ragoonanan, G.B. McKenna, R. Suryanarayanan. Correlation between Molecular Mobility and Physical Stability in Pharmaceutical Glasses. Mol Pharm, 13(4), 1267-1277 (2016).
• M. Mehta, G.B. McKenna, R. Suryanarayanan. Molecular mobility in glassy dispersions. J Chem Phys, 144(20), 204506 (2016).
• P. Mistry, R. Suryanarayanan. Strength of drug-polymer interactions: Implications for crystallization in dispersions. Cryst Growth Des, 16(9), 5141-5149 (2016).

2015

• N.K. Thakral, S. Mohapatra, G. Stephenson, R. Suryanarayanan. Compression-induced crystallization of amorphous indomethacin in tablets: Characterization of spatial heterogeneity by two-dimensional X-ray diffractometry. Mol Pharm, 12(1), 253-263 (2015).
• K. Kothari, V. Ragoonanan, R. Suryanarayanan. The role of drug-polymer hydrogen bonding interactions on the molecular mobility and physical stability of nifedipine solid dispersions. Mol Pharm, 12(1), 162-170 (2015).
• K. Kothari, V. Ragoonanan, R. Suryanarayanan. The role of polymer concentration on the molecular mobility and physical stability of nifedipine solid dispersions. Mol Pharm, 12(5), 1477-1484 (2015).
• P. Mistry, S. Mohapatra, T. Gopinath, F.G. Vogt, R. Suryanarayanan. Role of the strength of drug-polymer interactions on the molecular mobility and crystallization inhibition in ketoconazole solid dispersions. Mol Pharm, 12(9), 3339-3350 (2015). Recipient of the 2016 AAPS PPB Outstanding Manuscript Award.

2014

• S. Bhardwaj, K. Arora, E. Kwong, A. Templeton, S. Clas, R. Suryanarayanan. Mechanism of amorphous itraconazole stabilization in polymer solid dispersions: role of molecular mobility. Mol Pharm, 11(11), 4228-4237 (2014).
• S. Bhattacharya, S.P. Bhardwaj, R. Suryanarayanan. Molecular motions in sucrose-PVP and sucrose-sorbitol dispersions-II: implications of annealing on secondary relaxations. Pharm Res, 31(10), 2822-2828 (2014).
• K. Kothari, V. Ragoonanan, R. Suryanarayanan. Influence of molecular mobility on the physical stability of amorphous pharmaceuticals in the supercooled and glassy states. Mol Pharm, 11(9), 3048-3055 (2014).

2013

• S. Bhardwaj, K. Arora, E. Kwong, A. Templeton, A.D. Clas, R. Suryanarayanan. Correlation between molecular mobility and physical stability of amorphous itraconazole. Mol Pharm, 10(2), 694-700 (2013).
• S. Bhardwaj, R. Suryanarayanan. Molecular mobility as a predictor of the water sorption by annealed amorphous trehalose. Pharm Res, 30(3), 714-720 (2013).
• A. Saxena, Y.C. Jean, R. Suryanarayanan. Annealing effect reversal by water sorption–desorption and heating above the glass transition temperature - comparison of properties. Mol Pharm, 10(8), 3005-3012 (2013).

2012

• S. Bhardwaj, R. Suryanarayanan. Use of dielectric spectroscopy to monitor molecular mobility in glassy and supercooled trehalose. J Phys Chem, 116(38), 11728-11736 (2012).
• S. Bhardwaj, R. Suryanarayanan. Molecular mobility as an effective predictor of the physical stability of amorphous trehalose. Mol Pharm, 9(11), 3209-3217 (2012).

2011

• S. Bhattacharya, R. Suryanarayanan. Molecular motions in sucrose-PVP and sucrose-sorbitol dispersions: I. Implications of global and local mobility on stability. Pharm Res, 28(9), 2191-2203 (2011).
• S.P. Bhardwaj, R. Suryanarayanan. Subtraction of DC conductivity and annealing - Approaches to identify Johari-Goldstein relaxation in amorphous trehalose. Mol Pharm, 8(4), 1416-1422 (2011).