Amorphous Pharmaceuticals

Graphical abstract from “The Influence of the Strength of Drug-Polymer Interactions on the Dissolution of Amorphous Solid Dispersions.” published in Mol Pharm, 18(1), 174-186 (2021).
Reprinted with permission from Amponsah-Efah, Kweku K., et al. "The Influence of the Strength of Drug–Polymer Interactions on the Dissolution of Amorphous Solid Dispersions." Molecular pharmaceutics 18.1 (2020): 174-186. Copyright 2020 American Chemical Society
Publication YearCitation
2023R. Lalge, N. K. Kumar, R. Suryanarayanan. Understanding the Effect of Nucleation in Amorphous Solid Dispersions through Time–Temperature Transformation. Mol Pharm, 20(8), 4196-4209 (2023).
2023R. Lalge, N.K. Kumar and R. Suryanarayanan. Implications of Drug–Polymer Interactions on Time–Temperature–Transformation: A Tool to Assess the Crystallization Propensity in Amorphous Solid Dispersions. Mol Pharm, 20(3), 1806-1817 (2023).
2022J. Li, N.K. Duggirala, N.S. Krishna Kumar, Y. Su, R. Suryanarayanan, Design of ternary amorphous solid dispersions for enhanced dissolution of drug combinations. Mol Pharm, 19(8), 2950-2961 (2022).
2022R. Lalge, N. Kaur, N.K. Duggirala, R. Suryanarayanan, Dual functionality of bile acid: Physical stabilization of drugs in the amorphous form and solubility enhancement in solution. Mol Pharm, 19(7), 2595-2606 (2022).
2022N.S.K. Kumar, R. Suryanarayanan, Crystallization Propensity of Amorphous Pharmaceuticals: Kinetics and Thermodynamics. Mol Pharm, 19(2), 472-483 (2022).
2021K. K. Amponsah-Efah, P. Mistry, R. Eisenhart, R. Suryanarayanan, The Influence of the Strength of Drug-Polymer Interactions on the Dissolution of Amorphous Solid Dispersions. Mol Pharm, 18(1), 174-186 (2021).
2020A. Sahoo, R. Suryanarayanan, R.A. Siegel, Stabilization of amorphous drugs by polymers: The role of overlap concentration (C*). Mol Pharm, 17(11), 4401-4406 (2020).
2020K. K. Amponsah-Efah, B. Demeler, R. Suryanarayanan, Characterizing Drug-Polymer Interactions in Aqueous Solution with Analytical Ultracentrifugation, Mol Pharm, 18(1), 246-256 (2020).
2019A. Sahoo, N.S.K. Kumar, R. Suryanarayanan, Crosslinking: An avenue to develop stable amorphous solid dispersion with high drug loading and tailored physical stability. J Control Release, 311-312, 212-224 (2019).
2019

N.K. Duggirala, J. Li, N.S.K. Kumar, T. Gopinath, R. Suryanarayanan, A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability. Chem Commun, 55(39), 5551-5554 (2019).

*This article provided an inside back cover image for this issue upon request from the journal.

2018M. H. Fung, R. Suryanarayanan, Effect of organic acids on molecular mobility, physical stability and dissolution of ternary ketoconazole spray dried dispersions. Mol Pharm, 16(1), 41-48 (2018).
2018M.H. Fung, M. DeVault, K.T. Kuwata, R. Suryanarayanan, Drug-excipient interactions: effect on molecular mobility and physical stability of ketoconazole-organic acid coamorphous systems. Mol Pharm, 15(3), 1052-1061 (2018).
2018M.H. Fung, K. Bērziņš, R. Suryanarayanan, Physical stability and dissolution behavior of ketoconazole-organic acid coamorphous systems. Mol Pharm, 15(5), 1862-1869 (2018).
2018K. Berzins, R. Suryanarayanan, Compression-induced crystallization in sucrose-polyvinylpyrrolidone amorphous solid dispersions. Cryst Growth Des, 18(2), 839-848 (2018).
2017P. Mistry, K. K. Amponsah-Efah, R. Suryanarayanan, Rapid assessment of the physical stability of amorphous solid dispersions. Cryst Growth Des, 17, 2478-2485 (2017).
2017S. Mohapatra, S. Samanta, K. Kothari, P. Mistry, R. Suryanarayanan, Effect of polymer molecular weight on the crystallization behavior of indomethacin amorphous solid dispersions. Cryst Growth Des, 17(6), 3142-3150 (2017).
2017M.H. Fung, R. Suryanarayanan, Use of a plasticizer for physical stability prediction of amorphous solid dispersions. Cryst Growth Des,17(6), 4315-4325 (2017).
2016M. Mehta, R. Suryanarayanan, Accelerated physical stability testing of amorphous dispersions. Mol Pharm, 13(8), 2661-2666 (2016).
2016S. Thakral, M.W. Terban, N.K. Thakral, R. Suryanarayanan, Recent advances in the characterization of amorphous pharmaceuticals by X-ray diffractometry. Adv Drug Deliv Rev, 100: 183-193 (2016).
2016M. Mehta, K. Kothari, V. Ragoonanan, R. Suryanarayanan, Effect of Water on Molecular Mobility and Physical Stability of Amorphous Pharmaceuticals. Mol Pharm, 13(4), 1339-1346 (2016).
2016M. Mehta, V. Ragoonanan, G.B. McKenna, R. Suryanarayanan. Correlation between Molecular Mobility and Physical Stability in Pharmaceutical Glasses. Mol Pharm, 13(4), 1267-1277 (2016).
2016M. Mehta, G.B. McKenna, R. Suryanarayanan. Molecular mobility in glassy dispersions. J Chem Phys, 144:204506 (2016).
2016P. Mistry, R. Suryanarayanan. Strength of drug-polymer interactions: Implications for crystallization in dispersions. Cryst Growth Des, 16(9), 5141-5149 (2016).
2015N. Thakral, S. Mohapatra, G. Stephenson, R. Suryanarayanan, Compression-induced crystallization of amorphous indomethacin in tablets: Characterization of spatial heterogeneity by two-dimensional X-ray diffractometry. Mol Pharm, 12(1), 253-263 (2015).
2015K. Kothari, V. Ragoonanan, R. Suryanarayanan, The role of drug-polymer hydrogen bonding interactions on the molecular mobility and physical stability of nifedipine solid dispersions. Mol Pharm, 12(1), 162-170 (2015).
2015K. Kothari, V. Ragoonanan, R. Suryanarayanan, The role of polymer concentration on the molecular mobility and physical stability of nifedipine solid dispersions. Mol Pharm, 12(5), 1477-1484 (2015).
2015P. Mistry, S. Mohapatra, T. Gopinath, F.G. Vogt, R. Suryanarayanan, Role of the strength of drug-polymer interactions on the molecular mobility and crystallization inhibition in ketoconazole solid dispersions. Mol Pharm, 12(9), 3339-3350 (2015). Recipient of 2016 AAPS PPB Outstanding Manuscript award.
2014S. Bhardwaj, K. Arora, E. Kwong, A. Templeton, S. Clas, R. Suryanarayanan, Mechanism of amorphous itraconazole stabilization in polymer solid dispersions: role of molecular mobility. Mol Pharm, 11(11), 4228-4237 (2014).
2014S. Bhattacharya., S.P. Bhardwaj, R. Suryanarayanan, Molecular motions in sucrose-PVP and sucrose-sorbitol dispersions-II: implications of annealing on secondary relaxations. Pharm Res, 31(10), 2822-2828 (2014).
2014K. Kothari, V. Ragoonanan, R. Suryanarayanan, Influence of molecular mobility on the physical stability of amorphous pharmaceuticals in the supercooled and glassy states. Mol Pharm, 11(9), 3048-3055 (2014).
2013S. Bhardwaj, K. Arora, E. Kwong, A. Templeton, A.D. Clas, R. Suryanarayanan, Correlation between molecular mobility and physical stability of amorphous itraconazole. Mol Pharm, 10(2), 694-700 (2013).
2013S. Bhardwaj, R. Suryanarayanan, Molecular mobility as a predictor of the water sorption by annealed amorphous trehalose. Pharm Res, 30(3), 714-720 (2013).
2013A. Saxena, Y. C. Jean, R. Suryanarayanan, Annealing effect reversal by water sorption–desorption and heating above the glass transition temperature – comparison of properties. Mol Pharm, 10(8), 3005-3012 (2013).
2012S. Bhardwaj, R. Suryanarayanan, Use of dielectric spectroscopy to monitor molecular mobility in glassy and supercooled trehalose. J Phys Chem, 116(38), 11728-11736 (2012).
2012S. Bhardwaj, R. Suryanarayanan, Molecular mobility as an effective predictor of the physical stability of amorphous trehalose. Mol Pharm, 9(11), 3209-3217 (2012).
2011S. Bhattacharya, R. Suryanarayanan, Molecular motions in sucrose-PVP and sucrose-sorbitol dispersions: I. Implications of global and local mobility on stability. Pharm Res, 28(9), 2191-2203 (2011).
2011S.P. Bhardwaj, R. Suryanarayanan, Subtraction of DC conductivity and annealing – Approaches to identify Johari-Goldstein relaxation in amorphous trehalose. Mol Pharm, 8(4), 1416-1422 (2011).

Previous publications can be found on Professor Sury's Google Scholar page at this link.