Reprinted with permission from S. Thakral, J. Sonje, and R. Suryanarayanan. Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in colyophilized systems. Int J Pharm, 587, 119629 (2020).
2023
- D. Yong, J. Li, W. Xu, A. Cote, A. Lay-Fortenbery, R. Suryanarayanan, Y. Su. Solid-State NMR Spectroscopy to Probe State and Phase Transitions in Frozen Solutions. Mol Pharm, 20, 6380-6390 (2023).
- J. Li, J. Sonje, R. Suryanarayanan. Role of Poloxamer 188 in preventing ice-surface-induced protein destabilization during freeze-thawing. Mol Pharm, 20, 4587-4596 (2023).
2022
- J. Sonje, S. Thakral, B. Mayhugh, G. Sacha, S. Nail, J. Srinivasan, R. Suryanarayanan. Mannitol hemihydrate in lyophilized protein formulations: Impact of its dehydration during storage on sucrose crystallinity and protein stability. Int J Pharm, 624: 121974 (2022).
- J. Sonje, C.F. Chisholm, R. Suryanarayanan. Frozen storage of proteins: Use of mannitol to generate a homogenous freeze-concentrate. Int J Pharm, 630, 121995 (2022).
- A. Ukidve, K.B. Rembert, R. Vanipenta, P. Dorion, P. Lafarguette, T. McCoy, A. Saluja, R. Suryanarayanan, S. Patke. Succinate buffer in biologics products: Real-world formulation considerations, processing risks and mitigation strategies. J Pharm Sci, 112(1), 138-147 (2022).
- R. Lalge, N. Kaur, N.K. Duggirala, R. Suryanarayanan. Dual functionality of bile acid: Physical stabilization of drugs in the amorphous form and solubility enhancement in solution. Mol Pharm, 19(7), 2595-2606 (2022).
- S. Thakral, J. Sonje, B. Munjal, B. Bhatnagar, R. Suryanarayanan. Mannitol as an excipient for lyophilized injectable formulations. J Pharm Sci, 112(1), 19-35 (2022).
2021
- N.K. Duggirala, J. Sonje, X. Yuan, E. Shalaev, R. Suryanarayanan. Phase behavior of Poloxamer 188 in frozen aqueous solutions - Influence of processing conditions and cosolutes. Int J Pharm, 609, 121145 (2021).
- S. Thakral, J. Sonje, B. Munjal, R. Suryanarayanan. Stabilizers and their interaction with formulation components in frozen and freeze-dried protein formulations. Adv Drug Deliv Rev, 173, 1-19 (2021).
- N. Kaur, R. Suryanarayanan. Investigating the influence of excipients on the stability of levothyroxine sodium pentahydrate. Mol Pharm, 18(7), 2683-2693 (2021).
2020
- A.A. Thorat, B. Munjal, T.W. Geders, R. Suryanarayanan. Freezing-induced protein aggregation - Role of pH shift and potential mitigation strategies. J Control Release, 323, 591-599 (2020).
- J. Sonje, S. Thakral, R. Suryanarayanan. t-Butanol enables dual functionality of mannitol: A cryoprotectant in frozen systems and bulking agent in freeze-dried formulations. Mol Pharm, 17(8), 3075-3086 (2020).
- A. Sahoo, R. Suryanarayanan, R.A. Siegel. Stabilization of amorphous drugs by polymers: The role of overlap concentration (C*). Mol Pharm, 17(11), 4401-4406 (2020).
- K.K. Amponsah-Efah, C. Glorieux, J. Thoen, R. Suryanarayanan. Effect of glycerol on the order of the mesophase transitions of super-cooled itraconazole. J Mol Liquids, 114222 (2020).
- S. Thakral, J. Sonje, R. Suryanarayanan. Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in colyophilized systems. Int J Pharm, 587, 119629 (2020).
- B.S. Bhatnagar, J. Sonje, E. Shalaev, S.W.H. Martin, D.L. Teagarden, R. Suryanarayanan. A refined phase diagram of the tert-butanol-water system and implications on lyophilization process optimization of pharmaceuticals. Phys Chem Chem Phys, 22(3), 1583-1590 (2020).
2019
- A. Sahoo, N.S. Krishna Kumar, R. Suryanarayanan. Crosslinking: An avenue to develop stable amorphous solid dispersion with high drug loading and tailored physical stability. J Control Release, 311-312, 212-224 (2019).
- S. Koranne, J.F. Krzyzaniak, S. Luthra, K.K. Arora, R. Suryanarayanan. Role of conformer and excipient properties on the solid-state stability of theophylline cocrystals. Cryst Growth Des, 19(2), 868-875 (2019).
- A.A. Thorat, R. Suryanarayanan. Characterization of phosphate buffered saline (PBS) in frozen state and after freeze-drying. Pharm Res, 36(7), 98 (2019).
- R. Tanaka, N.K. Duggirala, Y. Hattori, M. Otsuka, R. Suryanarayanan. Formation of Indomethacin-Saccharin Cocrystals during Wet Granulation: Role of Polymeric Excipients. Mol Pharm, 17(1), 274-283 (2019).
2018
- S.S. Kulkarni, R. Suryanarayanan, J.V. Rinella Jr., R.H. Bogner. Mechanisms by which crystalline mannitol improves the reconstitution time of high concentration lyophilized protein formulations. Eur J Biopharm, 130, 70-81 (2018).
- M. H. Fung, R. Suryanarayanan. Effect of organic acids on molecular mobility, physical stability and dissolution of ternary ketoconazole spray dried dispersions. Mol Pharm, 16(1), 41-48 (2018).
- M.H. Fung, M. DeVault, K.T. Kuwata, R. Suryanarayanan. Drug-excipient interactions: effect on molecular mobility and physical stability of ketoconazole-organic acid coamorphous systems. Mol Pharm, 15(3), 1052-1061 (2018).
- K. Bērziņš, R. Suryanarayanan. Compression-induced crystallization in sucrose-polyvinylpyrrolidone amorphous solid dispersions. Cryst Growth Des, 18(2), 839-848 (2018).
- S. Thakral, S. Koranne, R. Suryanarayanan. Intra-vial heterogeneity in physical form of mannitol in colyophilized binary systems. Pharm Res, 35(11), 214 (2018).
2017
- S. Jena, J. Horn, R. Suryanarayanan, W. Friess, A. Aksan. Effects of excipient interactions on the state of the freeze-concentrate and protein stability. Pharm Res, 34(4), 462-478 (2017).
- S. Mohapatra, S. Samanta, K. Kothari, P. Mistry, R. Suryanarayanan. Effect of polymer molecular weight on the crystallization behavior of indomethacin amorphous solid dispersions. Cryst Growth Des, 17(6), 3142-3150 (2017).
- N.K. Duggirala, A. Vyas, J.F. Krzyzaniak, K.K. Arora, R. Suryanarayanan. Mechanistic insight into caffeine-oxalic cocrystal dissociation in formulations: Role of excipients. Mol Pharm, 14(11), 3879-3887 (2017).
2016
- S. Jena, R. Suryanarayanan, A. Aksan. Mutual influence of mannitol and trehalose on crystallization behavior in frozen solutions. Pharm Res, 33(6), 1413-1425 (2016).
2015
- K. Kothari, V. Ragoonanan, R. Suryanarayanan. The role of drug-polymer hydrogen bonding interactions on the molecular mobility and physical stability of nifedipine solid dispersions. Mol Pharm, 12(1), 162-170 (2015).
- K. Kothari, V. Ragoonanan, R. Suryanarayanan. The role of polymer concentration on the molecular mobility and physical stability of nifedipine solid dispersions. Mol Pharm, 12(5), 1477-1484 (2015).
- P. Mistry, S. Mohapatra, T. Gopinath, F.G. Vogt, R. Suryanarayanan. Role of the strength of drug-polymer interactions on the molecular mobility and crystallization inhibition in ketoconazole solid dispersions. Mol Pharm, 12(9), 3339-3350 (2015). Recipient of the 2016 AAPS PPB Outstanding Manuscript Award.
- N.K. Thakral, H. Yamada, G.A. Stephenson, R. Suryanarayanan. Spatial distribution of trehalose dihydrate crystallization in tablets by X-ray diffractometry. Mol Pharm, 12(10), 3766-3775 (2015).
2014
- S. Bhattacharya., S.P. Bhardwaj, R. Suryanarayanan. Molecular motions in sucrose-PVP and sucrose-sorbitol dispersions-II: implications of annealing on secondary relaxations. Pharm Res, 31(10), 2822-2828 (2014).
- R. Govindarajan, M. Landis, B. Hancock, L.A. Gatlin, R. Suryanarayanan, E.Y. Shalaev. Surface acidity and solid-state compatibility of excipients with an acid-sensitive API: case study of atorvastatin calcium. AAPS PharmSciTech, 16(2), 1-10 (2014).
2013
- S. Bhardwaj, R. Suryanarayanan. Molecular mobility as a predictor of the water sorption by annealed amorphous trehalose. Pharm Res, 30(3), 714-720 (2013).
- M. Mehta, S. Bhardwaj, R. Suryanarayanan. Controlling the physical form of mannitol in freeze-dried systems. Eur J Pharm Biopharm, 85(2), 207-213 (2013).
2012
- S. Bhardwaj, R. Suryanarayanan. Use of dielectric spectroscopy to monitor molecular mobility in glassy and supercooled trehalose. J Phys Chem, 116(38), 11728-11736 (2012).
- S. Bhardwaj, R. Suryanarayanan. Molecular mobility as an effective predictor of the physical stability of amorphous trehalose. Mol Pharm, 9(11), 3209-3217 (2012).
2011
- B.S. Bhatnagar, S.W.H. Martin, T.S. Hodge, T.K. Das, L. Joseph, D.L. Teagarden, E.Y. Shalaev, R. Suryanarayanan. Investigation of PEG crystallization in frozen and freeze-dried PEGylated recombinant human growth hormone-sucrose systems - Implications on storage stability. J Pharm Sci, 100(8), 3062-3075 (2011).
- P. Sundaramurthi, R. Suryanarayanan. Effect of crystallizing and non-crystallizing cosolutes on succinate buffer crystallization and the consequent pH shift in frozen solutions. Pharm Res, 28(2), 374-385 (2011).
- S. Bhattacharya, R. Suryanarayanan. Molecular motions in sucrose-PVP and sucrose-sorbitol dispersions: I. Implications of global and local mobility on stability. Pharm Res, 28(9), 2191-2203 (2011).
- S.P. Bhardwaj, R. Suryanarayanan. Subtraction of DC conductivity and annealing - Approaches to identify Johari-Goldstein relaxation in amorphous trehalose. Mol Pharm, 8(4), 1416-1422 (2011).
- P. Sundaramurthi, R. Suryanarayanan. Predicting the crystallization propensity of carboxylic acid buffers in frozen systems - Relevance to freeze drying. J Pharm Sci, 100(4), 1288-1293 (2011).
- P. Sundaramurthi, R. Suryanarayanan. Thermophysical properties of carboxylic and amino acid buffers at subzero temperatures: Relevance to frozen state stabilization. J Phys Chem B, 115(21), 7154-7164 (2011).
- A.M. Kaushal, V.R. Vangala, R. Suryanarayanan. Unusual effect of water vapor pressure on dehydration of dibasic calcium phosphate dihydrate. J Pharm Sci, 100(4), 1456-1466 (2011).