Formulations - Small Molecules

Graphical abstract from  “Microenvironmental Acidity: A Strategy to Mitigate Salt Disproportionation in Drug Product Environment.” published in Mol. Pharm., 17(4), 1324-1334, (2020).
Reprinted with permission from Koranne, Sampada, Rahul Lalge, and Raj Suryanarayanan. "Modulation of Microenvironmental Acidity: A Strategy to Mitigate Salt Disproportionation in Drug Product Environment." Molecular pharmaceutics 17.4 (2020): 1324-1334. Copyright 2020 American Chemical Society
Publication YearCitation
2023R. Lalge, N. K. Kumar, R. Suryanarayanan. Understanding the Effect of Nucleation in Amorphous Solid Dispersions through Time–Temperature Transformation. Mol Pharm, 20(8), 4196-4209 (2023).
2023B. Munjal, K. DeBoyace, F. Cao, J. F. Krzyzaniak, K. K. Arora, R. Suryanarayanan. Drug Phase Transformation and Water Redistribution during Continuous Tablet Manufacturing: A Case Study of Carbamazepine Dihydrate. Mol Pharm, 20(7), 3427-3437 (2023).
2023R. Lalge, N.K. Kumar and R. Suryanarayanan. Implications of Drug–Polymer Interactions on Time–Temperature–Transformation: A Tool to Assess the Crystallization Propensity in Amorphous Solid Dispersions. Mol Pharm, 20(3), 1806-1817 (2023).
2022J. Li, N.K. Duggirala, N.S. Krishna Kumar, Y. Su, R. Suryanarayanan, Design of ternary amorphous solid dispersions for enhanced dissolution of drug combinations. Mol Pharm, 19(8), 2950-2961 (2022).
2022R. Lalge, N. Kaur, N.K. Duggirala, R. Suryanarayanan, Dual functionality of bile acid: Physical stabilization of drugs in the amorphous form and solubility enhancement in solution. Mol Pharm, 19(7), 2595-2606 (2022).
2021N. Kaur, R. Suryanarayanan, Levothyroxine sodium pentahydrate tablets – formulation considerations. J Pharm Sci, 110(12), 3743-3756 (2021).
2021N. Kaur, R. Suryanarayanan, Investigating the influence of excipients on the stability of levothyroxine sodium pentahydrate. Mol Pharm, 18(7), 2683-2693 (2021).
2021K. K. Amponsah-Efah, P. Mistry, R. Eisenhart, R. Suryanarayanan, The Influence of the Strength of Drug-Polymer Interactions on the Dissolution of Amorphous Solid Dispersions. Mol Pharm, 18(1), 174-186 (2021).
2020N. Kaur, V.G. Young, Jr., Y. Su, R. Suryanarayanan, Partial dehydration of levothyroxine sodium pentahydrate in a drug product environment: Structural insights into stability, Mol Pharm, 17(10), 3915-3929 (2020).
2020S. Koranne, R. Lalge, R. Suryanarayanan, Modulation of Microenvironmental Acidity: A Strategy to Mitigate Salt Disproportionation in Drug Product Environment. Mol. Pharm., 17(4), 1324-1334, (2020).
2020A. Sahoo, R. Suryanarayanan, R.A. Siegel, Stabilization of amorphous drugs by polymers: The role of overlap concentration (C*). Mol. Pharm., 17(11), 4401-4406 (2020)
2020K. K. Amponsah-Efah, B. Demeler, R. Suryanarayanan, Characterizing Drug-Polymer Interactions in Aqueous Solution with Analytical Ultracentrifugation. Mol Pharm, 18(1), 246-256 (2020).
2020K. K. Amponsah-Efah, P. Mistry, R. Eisenhart, R. Suryanarayanan, The Influence of the Strength of Drug-Polymer Interactions on the Dissolution of Amorphous Solid Dispersions. Mol Pharm, 18(1), 174-186 (2020).
2020K. K. Amponsah-Efah, C. Glorieux, J. Thoen, R. Suryanarayanan, Effect of glycerol on the order of the mesophase transitions of super-cooled itraconazole. J Mol Liquids, 114222 (2020).
2019S. Koranne, J.F. Krzyzaniak, S. Luthra, K.K. Arora, R. Suryanarayanan, Role of conformer and excipient properties on the solid-state stability of theophylline cocrystals. Cryst Growth Des, 19(2), 868-875 (2019).
2019R. Tanaka, N.K. Duggirala, Y. Hattori, M. Otsuka, R. Suryanarayanan, Formation of Indomethacin-Saccharin Cocrystals during Wet Granulation: Role of Polymeric Excipients. Mol Pharm, 17(1):274-283 (2019).
2019N. Kaur, N.K. Duggirala, R. Suryanarayanan, The role of lattice disorder in water mediated dissociation of pharmaceutical cocrystal systems. Mol Pharm, 16(7), 3167-3177 (2019).
2019N.K. Thakral, S. Thakral, G.A. Stephenson, R. Sedlock, R. Suryanarayanan, Compression-induced polymorphic transformation in tablets: Role of shear stress and development of mitigation strategies. J Pharm Sci, 108(1), 476-484 (2019).
2019A. Sahoo, N.S.K. Kumar, R. Suryanarayanan, Crosslinking: An avenue to develop stable amorphous solid dispersion with high drug loading and tailored physical stability. J Control Release, 311-312, 212-224 (2019).
2019N.K. Duggirala, J. Li, N.S.K. Kumar, T. Gopinath, R. Suryanarayanan, A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability. Chem Commun, 55(39), 5551-5554 (2019).
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This article provided an inside back cover image for this issue upon request from the journal.
2018S. Koranne, S. Thakral, R. Suryanarayanan, Effect of Formulation and Process Parameters on the Disproportionation of Indomethacin Sodium in Buffered Lyophilized Formulations. Pharm Res, 35(1), 21 (2018).
2018S.A. Koranne, A. Sahoo, J.F. Krzyzaniak, S. Luthra, R. Suryanarayanan, Challenges in transitioning cocrystals from bench to bedside: Dissociation in prototype drug product environment. Mol Pharm, 15(8), 3297-3307 (2018).
2018M. H. Fung, R. Suryanarayanan, Effect of organic acids on molecular mobility, physical stability and dissolution of ternary ketoconazole spray dried dispersions. Mol Pharm, 16(1), 41-48 (2018).
2018M.H. Fung, M. DeVault, K.T. Kuwata, R. Suryanarayanan, Drug-excipient interactions: effect on molecular mobility and physical stability of ketoconazole-organic acid coamorphous systems. Mol Pharm, 15(3), 1052-1061 (2018).
2018M.H. Fung, K. Bērziņš, R. Suryanarayanan, Physical stability and dissolution behavior of ketoconazole-organic acid coamorphous systems. Mol Pharm, 15(5), 1862-1869 (2018).
2018A. Wolf, S. Thakral, K.E. Mulier, R. Suryanarayanan, G.J. Beilman, Evaluation of novel formulations of d-β-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock. Int J Pharm, 548(1), 104-112 (2018).
2017S. Koranne, R. Govindarajan, R. Suryanarayanan, Investigation of spatial heterogeneity of salt disproportionation in tablets by synchrotron X-ray diffractometry. Mol Pharm, 14(4), 1133-1144 (2017).
2017S. Mohapatra, S. Samanta, K. Kothari, P. Mistry, R. Suryanarayanan, Effect of polymer molecular weight on the crystallization behavior of indomethacin amorphous solid dispersions. Cryst Growth Des, 17(6), 3142-3150 (2017).
2017N.K. Duggirala, A. Vyas, J.F. Krzyzaniak, K.K. Arora, R. Suryanarayanan, Mechanistic insight into caffeine-oxalic cocrystal dissociation in formulations: Role of excipients. Mol Pharm, 14(11), 3879-3887 (2017).
2017M.H. Fung, R. Suryanarayanan, Use of a plasticizer for physical stability prediction of amorphous solid dispersions. Cryst Growth Des,17(6), 4315-4325 (2017).
2016M. Mehta, K. Kothari, V. Ragoonanan, R. Suryanarayanan. Effect of Water on Molecular Mobility and Physical Stability of Amorphous Pharmaceuticals. Mol Pharm, 13(4), 1339-1346 (2016).
2016M. Mehta, V. Ragoonanan, G.B. McKenna, R. Suryanarayanan. Correlation between Molecular Mobility and Physical Stability in Pharmaceutical Glasses. Mol Pharm, 13(4), 1267-1277 (2016).
2016N.K. Thakral, R.J. Behme, A. Aburub, J.A. Peterson, T.A. Woods, B.A. Diseroad, R. Suryanarayanan, G.A. Stephenson, Salt disproportionation in the solid state: Role of solubility and counterion volatility. Mol Pharm, 13(5), 4141-4151 (2016).
2016M. Mehta, R. Suryanarayanan, Accelerated physical stability testing of amorphous dispersions. Mol Pharm, 13(8), 2661-2666 (2016).
2015S. Thakral, R. Suryanarayanan, Salt formation during freeze-drying – an approach to enhance indomethacin dissolution. Pharm Res, 32(11), 3722-3731 (2015). Recipient of 2016 AAPS PPB Outstanding Manuscript award.
2015N. Thakral, S. Mohapatra, G. Stephenson, R. Suryanarayanan, Compression-induced crystallization of amorphous indomethacin in tablets: Characterization of spatial heterogeneity by two-dimensional X-ray diffractometry. Mol Pharm, 12(1), 253-263 (2015).
2015S. Patil, L.G. Lis, R.J. Schumacher, B.J. Norris, M.L Morgan, R.A. Cuellar, B.R. Blazar, R. Suryanarayanan, V.J. Gurvich, G.I. Georg, Phosphonooxymethyl prodrug of triptolide: Synthesis, physicochemical characterization, and efficacy in human colon adenocarcinoma and ovarian cancer xenografts. J Med Chem, 58(23), 9334-9344 (2015). Featured in ACS Editors' Choice.
2015K. Kothari, V. Ragoonanan, R. Suryanarayanan, The role of drug-polymer hydrogen bonding interactions on the molecular mobility and physical stability of nifedipine solid dispersions. Mol Pharm, 12(1), 162-170 (2015).
2015K. Kothari, V. Ragoonanan, R. Suryanarayanan, The role of polymer concentration on the molecular mobility and physical stability of nifedipine solid dispersions. Mol Pharm, 12(5), 1477-1484 (2015).
2015P. Mistry, S. Mohapatra, T. Gopinath, F.G. Vogt, R. Suryanarayanan, Role of the strength of drug-polymer interactions on the molecular mobility and crystallization inhibition in ketoconazole solid dispersions. Mol Pharm, 12(9), 3339-3350 (2015). Recipient of 2016 AAPS PPB Outstanding Manuscript award.
2014S. Bhardwaj, K. Arora, E. Kwong, A. Templeton, S. Clas, R. Suryanarayanan, Mechanism of amorphous itraconazole stabilization in polymer solid dispersions: role of molecular mobility. Mol Pharm, 11(11), 4228-4237 (2014).
2014R. Govindarajan, M. Landis, B. Hancock, L. Gatlin, R. Suryanarayanan, E. Shalaev, Surface acidity and solid-state compatibility of excipients with an acid-sensitive API: Case study of atorvastatin calcium. AAPS PharmSciTech, 16(2), 354-363 (2014).
2014K. Kothari, V. Ragoonanan, R. Suryanarayanan, Dielectric spectroscopy of small molecule pharmaceuticals – effect of sample configuration. J Pharm Sci, 103(10), 3190-3196 (2014).
2013N. Thakral, V. Ragoonanan, R. Suryanarayanan, Quantification, mechanism, and mitigation of active ingredient phase transformation in tablets. Mol Pharm, 10(8), 3128-3126 (2013).
2013K. Arora, S. Thakral, R. Suryanarayanan, Instability in theophylline and carbamazepine hydrate tablets: cocrystal formation due to release of lattice water. Pharm Res, 30(7), 1779-1789 (2013).
2013S. Bhardwaj, K. Arora, E. Kwong, A. Templeton, A.D. Clas, R. Suryanarayanan, Correlation between molecular mobility and physical stability of amorphous itraconazole. Mol Pharm, 10(2), 694-700 (2013).
2012P. Sundaramurthi, M. Burcusa, R. Suryanarayanan, Physical characterization of pentamidine isethionate during freeze-drying - Relevance to development of stable lyophilized product. J Pharm Sci, 101(5), 1732-1743 (2012).
2012P. Chakravarty, R. Suryanarayanan, R. Govindarajan, Phase transformation in thiamine hydrochloride tablets: Influence on tablet microstructure, physical properties, and performance. J Pharm Sci, 101(4), 1410-1422 (2012).
2011K.K. Arora, N.G. Tayade, R. Suryanarayanan, Unintended water mediated cocrystal formation in carbamazepine and aspirin tablets. Mol Pharm, 8(3), 982-989 (2011). Recipient of 2011 AAPS PPB Outstanding Manuscript award.
2011Z. Zong, S.D. Desai, A.M. Kaushal, D.H. Barich, Hong-Shian Huang, E.J. Munson, R. Suryanarayanan, L.E. Kirsch, The stabilizing effect of moisture on the solid-state degradation of gabapentin. AAPS PharmSciTech, 12(3), 924-931 (2011).

Previous publications can be found on Professor Sury's Google Scholar page at this link.