Reprinted with permission from S. Koranne, R. Lalge, and R. Suryanarayanan. Modulation of Microenvironmental Acidity: A Strategy to Mitigate Salt Disproportionation in Drug Product Environment. Mol Pharm, 17(4), 1324-1334 (2020).
2023
- R. Lalge, N.K. Kumar, R. Suryanarayanan. Understanding the Effect of Nucleation in Amorphous Solid Dispersions through Time-Temperature Transformation. Mol Pharm, 20(8), 4196-4209 (2023).
- B. Munjal, K. DeBoyace, F. Cao, J.F. Krzyzaniak, K.K. Arora, R. Suryanarayanan. Drug Phase Transformation and Water Redistribution during Continuous Tablet Manufacturing: A Case Study of Carbamazepine Dihydrate. Mol Pharm, 20(7), 3427-3437 (2023).
- R. Lalge, N.K. Kumar, R. Suryanarayanan. Implications of Drug–Polymer Interactions on Time–Temperature–Transformation: A Tool to Assess the Crystallization Propensity in Amorphous Solid Dispersions. Mol Pharm, 20(3), 1806-1817 (2023).
2022
- J. Li, N.K. Duggirala, N.S. Krishna Kumar, Y. Su, R. Suryanarayanan. Design of ternary amorphous solid dispersions for enhanced dissolution of drug combinations. Mol Pharm, 19(8), 2950-2961 (2022).
- R. Lalge, N. Kaur, N.K. Duggirala, R. Suryanarayanan. Dual functionality of bile acid: Physical stabilization of drugs in the amorphous form and solubility enhancement in solution. Mol Pharm, 19(7), 2595-2606 (2022).
2021
- N. Kaur, R. Suryanarayanan. Levothyroxine sodium pentahydrate tablets - formulation considerations. J Pharm Sci, 110(12), 3743-3756 (2021).
- N. Kaur, R. Suryanarayanan. Investigating the influence of excipients on the stability of levothyroxine sodium pentahydrate. Mol Pharm, 18(7), 2683-2693 (2021).
- K.K. Amponsah-Efah, P. Mistry, R. Eisenhart, R. Suryanarayanan. The Influence of the Strength of Drug-Polymer Interactions on the Dissolution of Amorphous Solid Dispersions. Mol Pharm, 18(1), 174-186 (2021).
2020
- N. Kaur, V.G. Young Jr., Y. Su, R. Suryanarayanan. Partial dehydration of levothyroxine sodium pentahydrate in a drug product environment: Structural insights into stability. Mol Pharm, 17(10), 3915-3929 (2020).
- S. Koranne, R. Lalge, R. Suryanarayanan. Modulation of Microenvironmental Acidity: A Strategy to Mitigate Salt Disproportionation in Drug Product Environment. Mol Pharm, 17(4), 1324-1334 (2020).
- A. Sahoo, R. Suryanarayanan, R.A. Siegel. Stabilization of amorphous drugs by polymers: The role of overlap concentration (C*). Mol Pharm, 17(11), 4401-4406 (2020).
- K.K. Amponsah-Efah, B. Demeler, R. Suryanarayanan. Characterizing Drug-Polymer Interactions in Aqueous Solution with Analytical Ultracentrifugation. Mol Pharm, 18(1), 246-256 (2020).
- K.K. Amponsah-Efah, P. Mistry, R. Eisenhart, R. Suryanarayanan. The Influence of the Strength of Drug-Polymer Interactions on the Dissolution of Amorphous Solid Dispersions. Mol Pharm, 18(1), 174-186 (2020).
- K.K. Amponsah-Efah, C. Glorieux, J. Thoen, R. Suryanarayanan. Effect of glycerol on the order of the mesophase transitions of super-cooled itraconazole. J Mol Liquids, 114222 (2020).
2019
- S. Koranne, J.F. Krzyzaniak, S. Luthra, K.K. Arora, R. Suryanarayanan. Role of conformer and excipient properties on the solid-state stability of theophylline cocrystals. Cryst Growth Des, 19(2), 868-875 (2019).
- R. Tanaka, N.K. Duggirala, Y. Hattori, M. Otsuka, R. Suryanarayanan. Formation of Indomethacin-Saccharin Cocrystals during Wet Granulation: Role of Polymeric Excipients. Mol Pharm, 17(1):274-283 (2019).
- N. Kaur, N.K. Duggirala, R. Suryanarayanan. The role of lattice disorder in water mediated dissociation of pharmaceutical cocrystal systems. Mol Pharm, 16(7), 3167-3177 (2019).
- N.K. Thakral, S. Thakral, G.A. Stephenson, R. Sedlock, R. Suryanarayanan. Compression-induced polymorphic transformation in tablets: Role of shear stress and development of mitigation strategies. J Pharm Sci, 108(1), 476-484 (2019).
- A. Sahoo, N.S. Krishna Kumar, R. Suryanarayanan. Crosslinking: An avenue to develop stable amorphous solid dispersion with high drug loading and tailored physical stability. J Control Release, 311-312, 212-224 (2019).
- N.K. Duggirala, J. Li, N.S. Krishna Kumar, T. Gopinath, R. Suryanarayanan. A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability. Chem Commun, 55(39), 5551-5554 (2019). *This article provided an inside back cover image for this issue upon request from the journal.
2018
- S. Koranne, S. Thakral, R. Suryanarayanan. Effect of Formulation and Process Parameters on the Disproportionation of Indomethacin Sodium in Buffered Lyophilized Formulations. Pharm Res, 35(1), 21 (2018).
- S.A. Koranne, A. Sahoo, J.F. Krzyzaniak, S. Luthra, R. Suryanarayanan. Challenges in transitioning cocrystals from bench to bedside: Dissociation in prototype drug product environment. Mol Pharm, 15(8), 3297-3307 (2018).
- M. H. Fung, R. Suryanarayanan. Effect of organic acids on molecular mobility, physical stability and dissolution of ternary ketoconazole spray dried dispersions. Mol Pharm, 16(1), 41-48 (2018).
- M.H. Fung, M. DeVault, K.T. Kuwata, R. Suryanarayanan. Drug-excipient interactions: effect on molecular mobility and physical stability of ketoconazole-organic acid coamorphous systems. Mol Pharm, 15(3), 1052-1061 (2018).
- M.H. Fung, K. Bērziņš, R. Suryanarayanan. Physical stability and dissolution behavior of ketoconazole-organic acid coamorphous systems. Mol Pharm, 15(5), 1862-1869 (2018).
- A. Wolf, S. Thakral, K.E. Mulier, R. Suryanarayanan, G.J. Beilman. Evaluation of novel formulations of d-β-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock. Int J Pharm, 548(1), 104-112 (2018).
2017
- S. Koranne, R. Govindarajan, R. Suryanarayanan. Investigation of spatial heterogeneity of salt disproportionation in tablets by synchrotron X-ray diffractometry. Mol Pharm, 14(4), 1133-1144 (2017).
- S. Mohapatra, S. Samanta, K. Kothari, P. Mistry, R. Suryanarayanan. Effect of polymer molecular weight on the crystallization behavior of indomethacin amorphous solid dispersions. Cryst Growth Des, 17(6), 3142-3150 (2017).
- N.K. Duggirala, A. Vyas, J.F. Krzyzaniak, K.K. Arora, R. Suryanarayanan. Mechanistic insight into caffeine-oxalic cocrystal dissociation in formulations: Role of excipients. Mol Pharm, 14(11), 3879-3887 (2017).
- M.H. Fung, R. Suryanarayanan. Use of a plasticizer for physical stability prediction of amorphous solid dispersions. Cryst Growth Des,17(6), 4315-4325 (2017).
2016
- M. Mehta, K. Kothari, V. Ragoonanan, R. Suryanarayanan. Effect of Water on Molecular Mobility and Physical Stability of Amorphous Pharmaceuticals. Mol Pharm, 13(4), 1339-1346 (2016).
- M. Mehta, V. Ragoonanan, G.B. McKenna, R. Suryanarayanan. Correlation between Molecular Mobility and Physical Stability in Pharmaceutical Glasses. Mol Pharm, 13(4), 1267-1277 (2016).
- N.K. Thakral, R.J. Behme, A. Aburub, J.A. Peterson, T.A. Woods, B.A. Diseroad, R. Suryanarayanan, G.A. Stephenson. Salt disproportionation in the solid state: Role of solubility and counterion volatility. Mol Pharm, 13(5), 4141-4151 (2016).
- M. Mehta, R. Suryanarayanan. Accelerated physical stability testing of amorphous dispersions. Mol Pharm, 13(8), 2661-2666 (2016).
2015
- S. Thakral, R. Suryanarayanan. Salt formation during freeze-drying - an approach to enhance indomethacin dissolution. Pharm Res, 32(11), 3722-3731 (2015). *Recipient of 2016 AAPS PPB Outstanding Manuscript award.
- N. Thakral, S. Mohapatra, G. Stephenson, R. Suryanarayanan. Compression-induced crystallization of amorphous indomethacin in tablets: Characterization of spatial heterogeneity by two-dimensional X-ray diffractometry. Mol Pharm, 12(1), 253-263 (2015).
- S. Patil, L.G. Lis, R.J. Schumacher, B.J. Norris, M.L Morgan, R.A. Cuellar, B.R. Blazar, R. Suryanarayanan, V.J. Gurvich, G.I. Georg. Phosphonooxymethyl prodrug of triptolide: Synthesis, physicochemical characterization, and efficacy in human colon adenocarcinoma and ovarian cancer xenografts. J Med Chem, 58(23), 9334-9344 (2015). Featured in ACS Editors' Choice.
- K. Kothari, V. Ragoonanan, R. Suryanarayanan. The role of drug-polymer hydrogen bonding interactions on the molecular mobility and physical stability of nifedipine solid dispersions. Mol Pharm, 12(1), 162-170 (2015).
- K. Kothari, V. Ragoonanan, R. Suryanarayanan. The role of polymer concentration on the molecular mobility and physical stability of nifedipine solid dispersions. Mol Pharm, 12(5), 1477-1484 (2015).
- P. Mistry, S. Mohapatra, T. Gopinath, F.G. Vogt, R. Suryanarayanan. Role of the strength of drug-polymer interactions on the molecular mobility and crystallization inhibition in ketoconazole solid dispersions. Mol Pharm, 12(9), 3339-3350 (2015). *Recipient of 2016 AAPS PPB Outstanding Manuscript Award.
2014
- S. Bhardwaj, K. Arora, E. Kwong, A. Templeton, S. Clas, R. Suryanarayanan. Mechanism of amorphous itraconazole stabilization in polymer solid dispersions: Role of molecular mobility. Mol Pharm, 11(11), 4228-4237 (2014).
- R. Govindarajan, M. Landis, B. Hancock, L. Gatlin, R. Suryanarayanan, E. Shalaev. Surface acidity and solid-state compatibility of excipients with an acid-sensitive API: Case study of atorvastatin calcium. AAPS PharmSciTech, 16(2), 354-363 (2014).
- K. Kothari, V. Ragoonanan, R. Suryanarayanan. Dielectric spectroscopy of small molecule pharmaceuticals - effect of sample configuration. J Pharm Sci, 103(10), 3190-3196 (2014).
2013
- N. Thakral, V. Ragoonanan, R. Suryanarayanan. Quantification, mechanism, and mitigation of active ingredient phase transformation in tablets. Mol Pharm, 10(8), 3128-3126 (2013).
- K. Arora, S. Thakral, R. Suryanarayanan. Instability in theophylline and carbamazepine hydrate tablets: cocrystal formation due to release of lattice water. Pharm Res, 30(7), 1779-1789 (2013).
- S. Bhardwaj, K. Arora, E. Kwong, A. Templeton, A.D. Clas, R. Suryanarayanan. Correlation between molecular mobility and physical stability of amorphous itraconazole. Mol Pharm, 10(2), 694-700 (2013).
2012
- P. Sundaramurthi, M. Burcusa, R. Suryanarayanan. Physical characterization of pentamidine isethionate during freeze-drying - Relevance to development of stable lyophilized product. J Pharm Sci, 101(5), 1732-1743 (2012).
- P. Chakravarty, R. Suryanarayanan, R. Govindarajan. Phase transformation in thiamine hydrochloride tablets: Influence on tablet microstructure, physical properties, and performance. J Pharm Sci, 101(4), 1410-1422 (2012).
2011
- K.K. Arora, N.G. Tayade, R. Suryanarayanan. Unintended water mediated cocrystal formation in carbamazepine and aspirin tablets. Mol Pharm, 8(3), 982-989 (2011). *Recipient of 2011 AAPS PPB Outstanding Manuscript Award.
- Z. Zong, S.D. Desai, A.M. Kaushal, D.H. Barich, H-S Huang, E.J. Munson, R. Suryanarayanan, L.E. Kirsch. The stabilizing effect of moisture on the solid-state degradation of gabapentin. AAPS PharmSciTech, 12(3), 924-931 (2011).