Reprinted with permission from A. Thorat and R. Suryanarayanan. Characterization of Phosphate Buffered Saline (PBS) in Frozen State and after Freeze-Drying. Pharm Res, 36(7), 98 (2019).
2023
- D. Yong, J. Li, W. Xu, A. Cote, A. Lay-Fortenbery, R. Suryanarayanan, Y. Su. Solid-State NMR Spectroscopy to Probe State and Phase Transitions in Frozen Solutions. Mol. Pharm, 20, 6380-6390 (2023).
- J. Li, J. Sonje, R. Suryanarayanan. Role of Poloxamer 188 in preventing ice-surface-induced protein destabilization during freeze-thawing. Mol. Pharm, 20, 4587-4596 (2023).
- D. Heger, R. Govindarajan, E. Lu, S. Ewing, A. Lay-Fortenbery, X. Yuan, L. Veselý, E. Munson, L. Gatlin, B. Hancock, R. Suryanarayanan. Beyond pH: Acid/Base Relationships in Frozen and Freeze-Dried Pharmaceuticals. InPrinciples and Practices of Lyophilization in Product Development and Manufacturing 2023 Apr 25 (pp. 39-61). Cham: Springer International Publishing.
- J. Sonje, S. Thakral, S. Krueger, R. Suryanarayanan. Enabling Efficient Design of Biological Formulations Through Advanced Characterization. Pharm Res, 40, 1459-1477 (2023).
- S. Thakral, J. Sonje, B. Munjal, B. Bhatnagar, R. Suryanarayanan. Mannitol as an excipient for lyophilized injectable formulations. J Pharm Sci, 112(1), 19-35 (2023).
- A. Ukidve, K.B. Rembert, R. Vanipenta, P. Dorion, P. Lafarguette, T. McCoy, A. Saluja, R. Suryanarayanan, S. Patke. Succinate buffer in biologics products: Real-world formulation considerations, processing risks and mitigation strategies. J Pharm Sci, 112(1), 138-147 (2023).
2022
- J. Sonje, S. Thakral, B. Mayhugh, G. Sacha, S. Nail, J. Srinivasan, R. Suryanarayanan. Mannitol hemihydrate in lyophilized protein formulations: Impact of its dehydration during storage on sucrose crystallinity and protein stability. Int J Pharm, 624, 121974 (2022).
- J. Sonje, C.F. Chisholm, R. Suryanarayanan. Frozen storage of proteins: Use of mannitol to generate a homogenous freeze-concentrate. Int J Pharm, 630, 121995 (2022).
- B. Munjal, S.M. Patel, R. Suryanarayanan. Role of arginine salts in preventing freezing-induced increase in subvisible particles in protein formulations. Int J Pharm, 619, 121694 (2022).
2021
- C. Staley, H. Halaweish, C. Graiziger, M. J. Hamilton, A. J. Kabege, A. L. Galdys, B. P. Vaughn, K. Vantanasiri, R. Suryanarayanan, M. J. Sadowsky, A. Khoruts. Lower endoscopic delivery of freeze-dried intestinal microbiota results in more rapid and efficient engraftment than oral administration. Sci Rep, 11(1), 4519 (2021).
- S.S. Kulkarni, S.M. Patel, R. Suryanarayanan, J.V. Rinella, Jr., R.H. Bogner. Key factors governing the reconstitution time of high concentration lyophilized protein formulations. Eur J Pharm Biopharm, 165, 361-373 (2021).
2020
- A. Thorat, B. Munjal, T.W. Geders, R. Suryanarayanan. Freezing-induced protein aggregation - Role of pH shift and potential mitigation strategies. J Control Release, 323, 591-599 (2020).
- S. Thakral, S. Sonje, R. Suryanarayanan. Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in co-lyophilized systems. Int J Pharm, 587, 119629 (2020).
- J. Sonje, S. Thakral, R. Suryanarayanan. t-Butanol enables dual functionality of mannitol: A cryoprotectant in frozen systems and bulking agent in freeze-dried formulations. Mol Pharm, 17(8), 3075-3086 (2020).
- B.S. Bhatnagar, J. Sonje, E. Shalaev, S.W.H. Martin, D.L. Teagarden, R. Suryanarayanan. A refined phase diagram of the tert-butanol-water system and implications on lyophilization process optimization of pharmaceuticals. Phys Chem Chem Phys, 22(3), 1583-1590 (2020).
- J.R. Snell, N.S. Krishna Kumar, R. Suryanarayanan, T.W. Randolph. Nanobubbles in reconstituted lyophilized formulations: Interaction with proteins and mechanism of formation. J Pharm Sci, 109(1), 284-292 (2020).
2019
- S. Jena, N.S. Krishna Kumar, A. Aksan, R. Suryanarayanan. Stability of lyophilized albumin formulations: Role of excipient crystallinity and molecular mobility. Int J Pharm, 569, 118568 (2019).
- A. Thorat, R. Suryanarayanan. Characterization of phosphate buffered saline (PBS) in frozen state and after freeze-drying. Pharm Res, 36(7), 98 (2019).
2018
- S. Thakral, S. Koranne, R. Suryanarayanan. Intra-vial heterogeneity in physical form of mannitol in colyophilized binary systems. Pharm Res, 35(11), 214 (2018).
- S.S. Kulkarni, R. Suryanarayanan, J.V. Rinella, Jr., R.H. Bogner. Mechanisms by which crystalline mannitol improves the reconstitution time of high concentration lyophilized protein formulations. Eur J Biopharm, 130, 70-81 (2018).
- S. Thakral, A. Wolf, G.J. Beilman, R. Suryanarayanan. Development and in vivo evaluation of a novel lyophilized formulation for the treatment of hemorrhagic shock. Int J Pharm, 537(1-2), 162-171 (2018).
- S. Koranne, S. Thakral, R. Suryanarayanan. Effect of Formulation and Process Parameters on the Disproportionation of Indomethacin Sodium in Buffered Lyophilized Formulations. Pharm Res, 35(1), 21 (2018).
2017
- S. Jena, J. Horn, R. Suryanarayanan, W. Friess, A. Aksan. Effects of excipient interactions on the state of the freeze-concentrate and protein stability. Pharm Res, 34(4), 462-478 (2017).
2016
- S. Jena, R. Suryanarayanan, A. Aksan. Mutual influence of mannitol and trehalose on crystallization behavior in frozen solutions. Pharm Res, 33(6), 1413-1425 (2016).
2015
- S. Thakral, R. Suryanarayanan. Salt formation during freeze-drying – an approach to enhance indomethacin dissolution. Pharm Res, 32(11), 3722-3731 (2015). Recipient of the 2016 AAPS PPB Outstanding Manuscript Award.
2014
- V. Ragoonanan, R. Suryanarayanan. Ultrasonication as a potential tool to predict solute crystallization in freeze-concentrates. Pharm Res, 31(6), 1512-1524 (2014).
2013
- M. Mehta, S. Bhardwaj, R. Suryanarayanan. Controlling the physical form of mannitol in freeze-dried systems. Eur J Pharm Biopharm, 85(2), 207-213 (2013).
2012
- P. Sundaramurthi, R. Suryanarayanan. Calorimetry and complimentary techniques to characterize frozen and freeze-dried systems. Adv Drug Del Rev, 63(13), 1118-1159 (2012).
- P. Sundaramurthi, M. Burcusa, R. Suryanarayanan. Physical characterization of pentamidine isethionate during freeze-drying - Relevance to development of stable lyophilized product. J Pharm Sci, 101(5), 1732-1743 (2012).
2011
- B.S. Bhatnagar, S.W.H. Martin, T.S. Hodge, T.K. Das, L. Joseph, D.L. Teagarden, E.Y. Shalaev, R. Suryanarayanan. Investigation of PEG crystallization in frozen and freeze-dried PEGylated recombinant human growth hormone-sucrose systems - Implications on storage stability. J Pharm Sci, 100(8), 3062-3075 (2011).
- P. Sundaramurthi, R. Suryanarayanan. Effect of crystallizing and non-crystallizing cosolutes on succinate buffer crystallization and the consequent pH shift in frozen solutions. Pharm Res, 28(2), 374-385 (2011).
- P. Sundaramurthi, R. Suryanarayanan. Predicting the crystallization propensity of carboxylic acid buffers in frozen systems – Relevance to freeze drying. J Pharm Sci, 100(4), 1288-1293 (2011).
- P. Sundaramurthi, R. Suryanarayanan. Thermophysical properties of carboxylic and amino acid buffers at subzero temperatures: Relevance to frozen state stabilization. J Phys Chem B, 115(21), 7154-7164 (2011).