The majority of drugs are administered as solid dosage forms. Our physical characterization studies, of both drugs and excipients, are aimed at improving the quality and robustness of pharmaceutical products. We are also interested in understanding the impact of pharmaceutical processing and formulation components on phase behavior, and in turn, the effect on product stability and performance. We also aim to identify the molecular basis of such transformations so as to develop robust mitigation strategies. While the active ingredient is of predominant concern, there are cases where phase transitions of excipients may be of relevance and importance. We employ a battery of analytical techniques, specifically, differential scanning calorimetry, thermogravimetric analysis, gravimetric water sorption, powder X-ray diffractometry (both laboratory and synchrotron sources), microscopy, and spectroscopy (IR, NMR and dielectric) for comprehensive material characterization.
Representative publications
- Thakral, Seema, Ramprakash Govindarajan, and Raj Suryanarayanan. "Processing‐Induced Phase Transformations and Their Implications on Pharmaceutical Product Quality." Polymorphism in the Pharmaceutical Industry: Solid Form and Drug Development (2018): 329-380.
- Kaur, Navpreet, and Raj Suryanarayanan. "Investigating the Influence of Excipients on the Stability of Levothyroxine Sodium Pentahydrate." Molecular Pharmaceutics (2021).
- Kaur, Navpreet, et al. "Partial dehydration of levothyroxine sodium pentahydrate in a drug product environment: structural insights into stability." Molecular Pharmaceutics 17.10 (2020): 3915-3929.
- Thakral, Seema, Jayesh Sonje, and Raj Suryanarayanan. "Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in colyophilized systems." International Journal of Pharmaceutics 587 (2020): 119629.
- Koranne, Sampada, Rahul Lalge, and Raj Suryanarayanan. "Modulation of Microenvironmental Acidity: A Strategy to Mitigate Salt Disproportionation in Drug Product Environment." Molecular Pharmaceutics 17.4 (2020): 1324-1334.
- Kaur, Navpreet, et al. "Role of lattice disorder in water-mediated dissociation of pharmaceutical cocrystal systems." Molecular Pharmaceutics 16.7 (2019): 3167-3177.
- Koranne, Sampada, et al. "Role of coformer and excipient properties on the solid-state stability of theophylline cocrystals." Crystal Growth & Design 19.2 (2019): 868-875.
- Thakral, Naveen K., et al. "Compression-induced polymorphic transformation in tablets: role of shear stress and development of mitigation strategies." Journal of Pharmaceutical Sciences 108.1 (2019): 476-484.